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Saturday, June 22, 2013

14:30 - 14:40

Welcoming and Opening Remarks
H. Peter Rodemann, Tübingen

14:40 - 16:00

Young Investigators Platform
Chair: H. Peter Rodemann, Tübingen

14:40 - 15:10

Invited Lecture
Deric Wheeler, Madison, USA
Targeting nuclear EGFR: Strategies for improving cetuximab therapy in cancer

15:10 - 15:30

Late-Breaking Paper
Saskia Rademakers, Nijmegen, NL
Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial

15:30 - 16:00

VARIAN-Juliana Denekamp Award Ceremony

15:30 - 15:40

Laudatio

15:40 - 16:00

VARIAN-Juliana Denekamp Award Lecture
Kasper Rouschop, Maastricht, NL
PERK-signaling and autophagy activation is required for survival of therapy resistant hypoxic cells

16:00 - 19:00

Topic I: Signaling Cascades and Survival Mechanisms
Chair: Randi Syljuasen, Oslo / Nils Cordes, Dresden

16:00 - 18:00 Poster Session
18:00 - 19:00 Proffered Papers
18:00 - 18:20 Bo Xu, Birmingham, USA
Hyperactive DNA damage response promotes breast cancer metastasis
18:20 - 18:40 Malin Lando, Oslo, NO
Genetic loss and hypermethylation of 3p genes as biomarkers of chemoradioresistance in cervical cancer
18:40 - 19:00 Barry Jütten, Maastricht, NL
Inhibition of autophagy abrogates the survival advantages of EGFRvIII+ cells under metabolic stress and sensitizes tumors to irradiation
19:30 Wolfsberg Barbecue

 

Sunday, June 23, 2013

08:00 - 12:00

Topic II: DNA Damage Response: Basic Mechanisms and Clinical Perspectives
Chair: Conchita Vens, Amsterdam / Ekkehard Dikomey, Hamburg

08:00 - 08:30

Invited Lecture
Bernard Salles, Toulouse, FR
A new way to follow the production of DNA double-strand breaks in cells in real time

08:30 - 09:00

Invited Lecture
Anthony Chalmers, Glasgow, UK
Tumor-specific radiosensitization by inhibition of PARP

09:00-11:00

Poster Session

11:00 - 12:00

Proffered Papers

11:00 - 11:20

Sandeep Burma, Dallas, USA
Phosphorylation of Exo1 by CDK1 and CDK2 regulates the choice between NHEJ and HR DNA repair pathways

11:20 - 11:40 Nathan T. Martin, Los Angeles, USA
ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response
11:40 - 12:00 Kum Kum Khanna, Brisbane, AUS
Essential developmental, genomic stability and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2
12:00 - 13:30 Lunch

 

Sunday, June 23, 2013

14.00 - 18:00

Topic III: Biomarkers and Targeting Strategies: Basic Mechanisms and Clinical Perspectives
Chair: Stephan Bodis, Aarau / Jens Overgaard, Aarhus

14.00 - 14:30

Invited Lecture
Anna Dubrovska, Dresden, GER
Cancer stem cells: A source of radioresistance and therapeutic target

14:30 - 15:00

Invited Lecture
Michael Baumann, Dresden, GER
Clinical perspectives of cancer stem cell research in radiation oncology

15:00 - 17:00

Poster Session

17:00 - 18:00

Proffered Papers

17:00 - 17:20

Philippe Lambin, Maastricht, NL
Mitochondrial DNA variation is a valuable biomarker for the development of radiation-induced lung toxicity

17:20 - 17:40

Paul M. Harari, Madison, USA
Combining radiation with next generation EGFR targeting agents: MEHD7945A and SYM004

17:40 - 18:00 C. Nicolaj Andreassen, Aarhus, DK
Independent prospective validation of a predictive test for risk of radiation in- duced fibrosis based on the gene expression pattern in fibroblasts irradiated in vitro
18:45 - 20:00 Wolfsberg Cup (sports event)
20:15 Wolfsberg Dinner

 

Monday, June 24, 2013

08:00 - 12:00

Topic IV: Tumor and Normal Tissue Microenvironment: Basic Mechanisms and Clinical Perspectives
Chair: Albert van der Kogel, Nijmegen / Bradly Wouters, Toronto

08:00 - 08:30

Invited Lecture
Thomas Iftner, Tübingen, GER
Role of HPV in cancer development

08:30 - 09:00

Invited Lecture
Jesper Eriksen, Odense, DK
Challenges in the treatment of HPV-positive head and neck squamous cell carci- nomas

09:00 - 11:00

Poster Session

11:00 - 12:00

Proffered Papers

11:00 - 11:20

Thorsten Rieckmann, Hamburg, GER
HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to impaired DSB repair capacity

11:20 - 11:40

Richard P. Hill, Toronto, CA
Hypoxia and metastasis in an orthotopic cervix cancer xenograft model

11:40 - 12:00

Marianne Koritzinsky, Toronto, CA
Reprogramming metabolism with metformin improves tumor oxygenation and radiation response

12:00 - 12:15 Presentation of the Wolfsberg Poster Awards and Closing Remarks
12:15 - 13:15 Lunch
13:30 Bus departure to Zürich Airport